Application of DNA-image cytometry in the differential diagnosis of urine cytology
WEI Shi-rong
WANG Qiu-shi
YANG Xin
ZHU Xiang-feng
XIAO Hua-liang
Abstract：Objective To investigate the clinical value of DNA-image cytometry (DNA-ICM) in the diagnosis of urinary cytology and to improve the clinical diagnostic rate of urothelial cell carcinomnas.Methods A total of 395 patients with urinary system diseases admitted to our hospital were detected with urine thin-layer cytology test (TCT) and DNA-ICM,respectively.And we compared the results between the 2 methods above mentioned.Patients with abnormal results needed histological biopsy.Results The positive rates,sensitivity and specificity of DNA-ICM were 48.9％ (192/395),94.6％ (192/203) and 51.4％ (203/395) in the diagnosis of UCC but those ofTCT were 28.1％ (110/395),38.4％(110/285) and 72.2％ (285/395),respectively.The sensitivity of DNA-ICM was significantly higher than that of TCT and the difference was statistically significant (P ＜ 0.01).The biopsy results showed that the diagnostic accuracy of DNA-ICM was 97.2％,91.3％ and 80.1％.Conclusion DNA-ICM,which improves the detective rate of urinary cytology,has great application value in the diagnosis of urothelial cell carcinomas.Combined examination of DNA-ICM and TCT will improve the detectable rate and accuracy of urinary cytology and reduce false negative results.
Keywords：UrineExfoliated cellsCytologyQuantitative analysis of DNA
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 285-288 )