Pseudovascular squamous cell carcinoma of tongue: a clinicopathological analysis
WANG Yun
YANG Li
LU Yun-long
QIU Xiao-mei
LIU Mei
Abstract：Objective To investigate the clinical and pathological features,diagnosis and differential diagnosis,treatment and prognosis of pseudovascular squamous cell carcinoma (PSCC).Methods One case of pseudovascular squamous cell carcinoma of the tongue was reported for the first time.The morphological features,immunohistochemistry and special staining results were described.And also the literatures were reviewed in order to summarize the clinicopathological features and prognosis of this type of tumor.Results A 56-year-old female patient with a polypoid tumor on the anterior portion of the tongue,measuring 6 cm × 5 cm× 1.5 cm,was admitted to our hospital.Microscopiclly,the tumor was characterized with marked acantholysis.Most area of the tumor was angioma-like.The cavity was lined with epithelioid or hobnail tumor cells and the lumina of these spaces contained tumor cells,lots of erythrocytes and inflammatory cells.These tumor cells were epithelioid or spindle,with marked nucleolus.Mitotic figures were common (＞20/10HPF).Immunohistochemistry revealed that the tumor cells were diffusely positive for CK,CK5/6,p63,vimentin,CD56 and CD99,but negative for EMA,CD34,CD31,E-cadherin and other markers of myogenic,neurogenic and melanin.The index of Ki-67 was about 70％.AB staining was positive while PAS was negative.Conclusions Pseudovascular squamous cell carcinoma is a rare type of squamous cell carcinoma,and it may be a special subtype of acantholytic squamous cell carcinoma.This tumor has special histological characteristics.Immunohistochemistry can help to distinguish it from angiosarcoma and other soft tissue sarcomas or carcinomas.The metastasis and recurrence rate of pseudovascular squamous cell carcinoma is high and the prognosis is poor.Extended resection should be performed inluding regional lymph node dissection.The effect of radiotherapy and chemotherapy is uncertain.
Keywords：Pseudovascular squamous cell carcinomaTongueClinical pathologyDiagnosis and differential diagnosisImmunohistochemistry
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 251-255,260 )