Primary cutaneous CD4 positive small/medium T cell lymphoproliferative disorder:a clinicopathological analysis
MA Qiang
FANG San-gao
CHENG Qiong-hui
ZHAO Lian-hua
ZHU Xiang-feng
XIAO Hua-liang
Abstract：Objective To investigate the clinicopathologic features,morphological characteristics and differential diagnosis of primary cutaneous CD4 positive small/medium-sized pleomorphic T-cell lymphoproliferative disorder (CD4 +PCSM-TCLD).Methods The clincopathologic and histological features,immunological phenotype of 3 cases of CD4 +PCSM-TCLDs were studied and the related literatures were reviewed,and the diagnosis and differential diagnosis were concluded.Results The ages of these 3 cases ranged from 29 to 47 years (median 40.6 years) and male to female ratio was 1∶ 2.All of these 3 tumors' sites were head and neck.The main clinical symptom was single nodule and local erythema.Histologically,CD4 + PCSM-TCLD typically featured nodular infiltrates involving the deep dermis,which were composed of mild to moderate cytologic atypia lymphoid cells.Meanwhile,there were mixed eosinophils and histiocytes in the stroma.Immunohistochemically,lymphocytes were positive for CD3 and CD4,and focally positive for CD5,CD7,CD8,CD2,CXCL-13 and PD1.But no lymphocytes were positive for EB virus RNA.Less than 20％ of lymphocytes were positive for Ki-67.Clonal TCR rearrangement was detected in two cases.Conclusion CD4 + PCSM-TCLD as a rare lymphoproliferative disorder may be the same clinical pathological manifestation of many diseases so that this lesion is only a provisional entity in the 2016 WHO classification.CD4 + PCSM-TCLDs are usually solitary lesions with a slow course and well prognosis after complete resection.
Keywords：Primary cutaneous CD4 positive small/medium T cell lymphoproliferative disorderLymphomaDifferential diagnoses
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 246-250 )