Clinico-pathological characteristics of intrahepatic biliary adenofibroma with malignant transformation
XU Qian
LIU Hong-gang
HE Chun-yan
Abstract：Objective To observe the clinico-pathological characteristics of biliary adenofibroma (BAF) and its differential diagnosis.Methods A rare ease of BAF was reported and the clinicopathological features were analyzed with review of related literature.Results A 83 year-old man complained of type-B ultrasonic discovering 2 cm × 1 cm hepatic mass 10 years ago without any symptom and therapy.He was in hospital this time,because MRI showed a quasicircular,low-density,well-circumscribed,6.2 cm * 3 cm.6 * 3.3 cm mass in the left lobe of liver.Histologically,the tumor was composed of glandular tubulo-acinar and cystic structures lined by a monolayered cuboidal to low columnar non-mucous biliary-type epithelium,embedded in a moderately cellular fibrous stroma.There were multiple foci of epithelial atypia that represented low to high grade dysplasia.A small focus of in situ and tiny invasive carcinoma probably exited.Conclusions BAF is a rarely benign tumor derived from interhepatic duct and might be able to develop malignant transformation and even distant metastasis.Imaging studies are nonspecific and cannot distinguish BAF from other hepatic tumors.The key to diagnosis of BAF is mainly based on histological examination.
Keywords：Biliary adenofibromaMalignant transformationDifferential diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 196-200 )