Clinicopathological characteristics of chondromyxoid fibroma of the head and neck : an analysis of seven cases

LIU Jin-hong; CHENG Lan-yun; DENG Jin-fang; SHI Huai-yin

doi:10.3969/j.issn.1007-8096.2018.03.005

Abstract：Objective To study the clinicopathological features and differential diagnosis of chondromyxoid fibroma (CMF) of the head and neck.Methods The clinicopathological data nere collected in 7 cases of CMF of the head and neck.The clinieal presentation and morpholgical features were analyzed with review of related literature.Results In the 7 cases,4 male and 3 female were included,ages 17 to 58 years,and the median age was 35 years.2 cases of CMF located in skull base bone,2 in mastoid process,1 in cervical vertebrae,1 in jaw bone and 1 in the right side of cranio-orbital region.Pain and swelling were common presenting symptoms.The imaging of CMF presented as a round-like mass.Most of the CMF was domed,grey and semitransparent soft mass,with poor vascular supply and local bone destruction.The histopathological features of CMF included lobulated structure,rich in mucus chondroid matrix.The tumor cells were elongated or star-like shape,high cellularity in the center,low cellularity in the circum.Multinuclear giant cell,calcium deposition and hemorrhage were common.The tumor cells demonstrated immunoreactivity for vimentin and S-100.At the end of study,4 out of 7 cases were lost to follow-up and the remaining 3 cases were followed up for 5 years,4 years and 8 months,2 months respectively;so far there was no recurrence.Conclusions Chondromyxoid fibroma is a rare chondrogenic benign tumor,while even rare in the head and neck.It should be distinguished from bone tumor,especially malignant cartilage tumor.Therefore,histological and radiographic appearance plays important roles in diagnosis of this tumor.