Lipofibromatosis: a clinicopathological study of six cases
LUO Dong-yun
NIU Li-hua
LI Li
ZHAO Zhi-hua
Abstract：Objective To study the clinicopathologic features,diagnosis and differential diagnosis of lipofibromatosis.Methods The clinical data,histology,immunohistochemistry of six cases of lipofibromatosis were analysed and discussed with associated literature.Results Six cases of lipofibromatosis included 5 male and 1 female,of whom three patients were found a lump after born soon,two at one year old and one at three years old.The main clinical manifestations were slow-growing local mass with no tenderness.Histologically,the tumor was mainly composed of mature adipose tissue and fibroblasts.Immunohistochemically,of the six cases of lipofibromatosis,the tumor cells both showed diffuse positivity for Vimentin,3 cases showed positivity for Bcl-2 and CD99,2 cases revealed expression of CD34,SMA and S-100,and 1 case showed diffuse positivity for CD68 and β-Catenin,while no expression of Desmin,CK,Caldesmon or MSA presented.Conclusion The lipofibromatosis is a rare soft tissue tumor,with a high risk of local recurrence but no distent metastasis.The accurate diagnosis mainly depends on the pathological histology and immunohistochemical markers.
Keywords：LipofibromatosisInfantClinicopathologyImmunohistochemistry
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 133-136 )