Pagetoid reticulosis: a clinical and pathologic analysis
WEI Shu-fei
XU Xiao
WANG Liang-liang
HUANG Wen-yong
ZHANG Xiao-rong
CAO Fang
LI Ting
Abstract：Objective To analyze the clinical and pathological characteristics,diagnosis and differential diagnosis of disseminated pagetoid reticulosis (PR).Methods One case of PR was collected,the clinical and pathological features were investigated with review of the related literatures.Results The lesion was characterized by over hyperplasia of epidermis with hyperkeratosis,parakeratosis and acanthosis.The surface epithelium was infiltrated by medium-sized atypical lymphocytes with abundant and pale eosinophilic cytoplasm,gyriform nuclei,partially visible nucleoli;they were dispersed throughout the epidermis,singly,two to three cells or in small nests.The basement membrane was integfitied,and the superficial corium contained a large number of mature lymphocytes and some atypical lymphocytes around the blood vessel.Tumor cells were positive for CD2,CD5,CD3,CD20,CD30,CD4,focally positive CD8,and negative for CD7,TIA-1,GrB,CD56,TCRαβ,ALK,EMA,and TCRγδ.Ki-67 proliferative index was over 50％.Conclusion PR is a rare variant of mycosis fungoides and indolent cutaneous T-cell lymphoma.
Keywords：Disseminated pagetoid reticulosisMycosis fungoidesPathological characteristics
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 126-128 )