Characteristics of thyroid-like follicular renal cell carcinoma: a clinicopathologic analysis of four cases

LIAN Jing; WANG Li-xia; MA Hai-xia; WANG Xiao-juan; WANG Qi-feng

doi:10.3969/j.issn.1007-8096.2018.02.007

Abstract：Objective To study the clinicopathologic features of thyroid-like follicular renal cell carcinoma.Methods Clinical data were collected in four patients with thyroid-like follicular renal cell carcinoma.HE and immunohistochemistry were carried out in surgically removed specimen to analyze the pathological morphological characteristics with review of related literature.Resuls The patients aged 37-66 years,with three males and one female.The tumors occurred in the unilateral kidney with three in the left and one in the right.Tumor maximum diameters of two surgically-removed were 4 cm and 2 cm,respectively.Another 2 case were consultation cases and not provided tumor size.Microscopically,most of tumor cells arranged in thyoid follicular pattern in different sizes,with irregular shape or miscarriage papillary structure in partial enlongated follicular pattern.The follicule-like structure was filled with eosinophilic colloid-like material,lined by a single layer of cuboidal or columnar cells,with not obvious atypia,and rare mitosis.hnmuohistochemical staining showed that tumor cells were negative for thyroid transcription factor1 (TTF1) and thyroglobulin (TG),and positive in different degree for CD10,Vimentin,PAX8,CK7,P504S and CD117.Three patients were followed up for 15-25 months,showing no tumor progression.Conclusions Thyroid-like follicular renal cell carcinoma is a low-grade primary renal epithelial malignant tumor.The pathological diagnosis needs comprehensive evaluation by combining its clinical history,imaging examination and immunohistochemical markers.