Clinicopathologic features of solitary fibrous tumor in vulva
LIU Dan
WANG Jian
DAI Zhao-hui
TIAN Xiu-chun
XIAO Qin
WANG Cui-mei
GU Xue-wen
Abstract：Objective To study the clinicopathogic features and differential diagnosis of primary solitary fibrous tumor (SFT) in vulva.Methods The clinical data and pathologic characteristics of two cases of SFT in the vulva were analyzed,and the relevant literatures were reviewed.Results The age was 53 and 65 years,respectively.The lesions were well circumscribed and painless in subcutaneous,presented over the left labia majora and mons pubis.The diameter of the tumors were ranged from 3.5 to 4.5 cm (median 4 cm).Microscopically,the tumor exhibited a patternless arrangement of fibroblastic spindle cells in a hyalinized collagenous matrix and rich of scattered blood vessels,but no obvious hemangiopericytoma-like structure.Focally,myxoid appearance was in the stroma,no atypical mitoses and necrosis were observed.Immunohistochemically,the tumor spindle cells were positive for CD34,STAT6,CD99,bcl-2 and vimentin.All two cases with follow-up did not show any tumor recurrence or metastasis.Conclusions SFT is rare in vulva,and more rare with myxoid stromal change.The most patients show good prognosis.SFT expresses CD34 and STAT6 and needs to be distinguished from other spindle cell tumors.
Keywords：Vulvar neoplasmImmunohistochemistryDiagnosisDifferential diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 45-48 )