Mixed thyroid carcinoma: a clinicopathological analysis of 4 cases
WANG Jing
MIAO Yu-chun
LI He
LIAN Jing
XU En-wei
YANG Xuan-qin
Abstract：Objective To investigate the clinical and pathological characteristics,immunophenotype,diagnosis,treatment and prognosis in 4 caese of mixed thyroid carcinoma.Methods Clinical and pathological data were retrospectively analyzed in 4 cases of mixed thyroid carcinoma.The expression of TG,TrF-1,calcitonin,Syn,CGA,galectin-3,mesothelia,CK19,TPO,CD56,B-raf and Ki-67 were detected by a full automatic immunostainer.And the related literatures were reviewed.Results The 4 patients were female.There were 2 cases of mixed medullary carcinoma with papillary carcinoma,1 case of mixed medullary carcinoma and minimally invasive follicular carcinoma,and another 1 case of mixed of papillary thyroid carcinoma and minimally invasive follicular carcinoma.Immunophenotyping showed that calcitonin,SYN and CGA were expressed in medullary carcinoma region;TG and TTF-1 were expressed in follicular carcinoma region,where calcitonin,Syn and CGA were not expressed;galectin-3,mesothelia,CK19 and B-raf were expressed in papillary carcinoma region where TPO,CD56,calcitonin,Syn and CGA were not expressed.Conclusion Two different types of thyroid cancer mixed happens very rare,which has a variety of theories.Immunohistochemical markers can assist in the diagnosis.
Keywords：Mixed thyroid carcinomaMedullary carcinoma of thyroid glandThyroid papillary carcinomaThyroid follcular carcinoma
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 22-24 )