Expression of Fascin protein in NSCLC and its clinical significance
SONG Li-li
XU Kai
HE Miao
Abstract：Objective To study the expression of Fascin protein in human NSCLC and its relationship with clinical pathological characteristics.Methods 73 cases of NSCLC were collected with 30 cases of adjacent tissues.The expression of protein in NSCLC tissues and the relationship between the expression of Fascin protein in NSCLC tissues and the clinical pathological characteristics were analyzed by immunohistochemistry.Results The expression of Fascin protein in NSCLC tissues was strongly positive in 16 cases,positive in 18 cases,weakly positive in 22 cases,and positive rate of 69.86％ cases.In 26 cases of the adjacent tissues,positive expression was 4 cases(13.3％).Positive expression rate of Fascin protein in NSCLC tissues was significantly higher than that of adjacent tissues (P ＜ 0.05).The positive expression of Fascin protein in NSCLC was not related to the age,gender,smoking history,tumor size,histological type (P ＞ 0.05),but related to TNM stage,lymph node metastasis and histological differentiation degree of patients (P ＜ 0.05).Conclusion The expression of Fascin protein in NSCLC tissues is associated with the stage,differentiation and lymph node metastasis of NSCLC.
Keywords：Fascin proteinNSCLCExpressionClinicopathological features
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 828-830,836 )