Bronchoalveolar lavage fluid application value of tumor markers detection in lung cancer

REN Fang-ping; JIANG Yan-wen

doi:10.3969/j.issn.1007-8096.2017.10.013

Abstract：Objective To explore the value of tumor markers' concentration in bronchoalveolar lavage fluid (BALF) in lung cancer diagnosis and pathological types and clinical stages.Method 78 patients were diagnosed by histopathological and cytological results as lung cancer group,72 patients with benign lesions of the lung as control group,both groups were measured the concentration of carcinoembryonic antigen,soluble intracellular keratin 19 pieces,neuronspecific enolase,squamous cell carcinoma-related antigen by enzyme-linked immunosorbent assay in two groups of patients in BALF and serum.Results Serum CEA,CYFRA21-1,NSE,SCC concentration in lung cancer group were significantly higher than the control group with statistically significant(P ＜ 0.05).The CEA,CYFRA21-1,NSE,SCC concentration of BALF in lung cancer group were significantly higher than the control group with statistically significant (P ＜ 0.05).The CEA,CYFRA21-1,NSE,SCC concentration of lung cancer group in BALF were higher than in serum with statistically significant (P ＜ 0.05).The CEA levels in adenocarcinoma was the highest,the CYFRA21-1 and SCC in squamous cell carcinoma of the highest concentration,the NSE concentration was the highest in small cell lung cancer in serum and BALF from lung cancer patients with statistically significant (P ＜ 0.05).The concentration of CEA,CYFRA21-1,NSE,SCC in BALF on lung cancer stage Ⅰ and Ⅱ,Ⅲ,Ⅳ in lung Cancer Group showed a statistically significant difference (P ＜ 0.05);Compared with stage Ⅰ,patients on stage Ⅱ,m and Ⅳ had higher markers levels in the BALF with statistically significant (P ＜ 0.05).Conclusion The detection of CEA,CYFRA21-1,NSE and SCC in BALF in early diagnosis of lung cancer is superior to serum.Detection of tumor markers in BALF has clinical value in speculating the pathology,clinical staging and prognosis.