Expressions and significance of IgG, IgG1 and IgG4 in membranous nephropathy

WANG Fang-ping; TIAN-Gui; ZHANG Yun-xiang

doi:10.3969/j.issn.1007-8096.2017.10.011

Abstract：Objective To investigate the expression of IgG,IgG1 and IgG4 in membranous nephropathy (MN),and to retrospectively analyze its significance and value of differential diagnosis in membranous nephropathy (MN).Methods A total of 144 cases of membranous nephropathy diagnosed by renal biopsy pathology (immunofluorescence,light microscopy,and electron microscopy) in Weifang People's Hospital from August 2015 to July 2017 were included in the study.The expression of IgG,IgG1 and IgG4 was determined by immunohistochemistry,and retrospectively analyzed,combined with the clinical data and pathological features.Their value in the differential diagnosis of MN was evaluated.Results A total of 144 cases were included,that MN-Ⅰ accounted for 81.94％,MN-Ⅱ accounted for 16.67％ and MN-Ⅲ accounted for 1.39％.IgG subtypes in each phase of the distribution of MN:IgG positive rate (98.31％) was the highest in the MN-Ⅰ,the second is the IgG4 (86.44％).The positive rate was significantly higher than that of IgG1 (49.15％),IgG and IgG4.The difference was statistically significant (P ＜ 0.05).In MN-Ⅱ,IgG positive rate (100％) was the highest,followed by IgG4 (87.50％),IgG positive rate was significantly higher than that of IgG1 (70.83％).The difference was statistically significant (P ＜ 0.05).In MN-Ⅲ,IgG,IgG1 positive rate(100％) was the highest,followed by IgG4 (50.0％).The positive rate was significantly higher than that of IgG4 (50.0％),IgG and IgG1.The difference was statistically significant (P ＜ 0.05).Conclusions Determined by immunohistochemistry,IgG is mainly expressed in MN-Ⅰ group,IgG and IgG4 are mainly expressed in MN-Ⅱ group,IgG and IgG1 are mainly expressed in MN-Ⅲ group.IgG,IgG1 and IgG4 in MN show a high positive concordance rate,contribute to the differential diagnosis of periods of membranous nephropathy.