Primary NK/T cell lymphoma of the testis: clinical and pathological analyses
ZHONG Peng
ZENG Ying
MA Qiang
LIN Li
LUO Qing-ya
XIAO Hua-liang
Abstract：Objective To investigate clinicopathologic features and differential diagnosis of primary NK/T cell lymphoma of the testis.Methods The clinical and radiological data were collected in three cases of primary testicular NK/T cell lymphoma and their pathological and immunohistochemical features analyzed,and the pathological diagnosis and differential diagnosis were discussed based on related literature review.Results Three cases were old men,and the three lesions were located in the left,right testis and bilateral testes respectively.Histologically,the normal structure of testis was destructed,distance between residual seminiferous tube was broaden,tumor cells grown diffusely,and showed an angiodestructive growth pattern and infiltrated the vessel wall;tumor cells were composed by small,medium and large cells with round,irregular shaped,rod-shaped nucleus surrounded by clear or eosinophilic cytoplasm,with high mitoses.The neoplastic cells were positive for CD2,cytoplasmic CD3 (CD3ε),CD43,CD45RO,CD56,GrB,TIA-1,Perforin and EBER,while the expression of CD57,CD20,CD79a,PLAP,CK,MPO,BCL-2 and TDT was negative.Conclusion Primary NK/T cell lymphoma of the testis is a rare entity and progresses rapidly,with a poor prognosis.The expression of CD2,CD3ε,CD56,GrB and EBER play an important role in diagnosis.
Keywords：NK/T cell lymphomaPrimaryTestisEpstein-barr virus in situ hybridization
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 731-736 )