Rosai-Dorfman disease in the breast: a clinicopathologic analysis of four cases
LIU Mei
LI Xi-ru
LI Ying
CHENG Liu-quan
ZHENG Yi-qiong
SONG Xin
WU Yun
Abstract：Objective To elucidate the relationship between Rosai-Dorfman disease (RDD) and IgG4-related disease (IgG4RD).Methods The histological features of 4 cases of RDD in the breast were analyzed and the numbers of IgG4 + plasma cells and IgG4/IgG ratios were evaluated.Serum IgG4 concentrations were also measured in two of the cases.Results Two cases (cases 1 and 2) showed features of IgG4RD,including lymphoid follicle formation with regressive changes,obliterative phlebitis,increased number of IgG4 + plasma cells,and increased IgG4/IgG ratio;Case 1 showed elevated serum IgG4 level.Amyloidosis was detected in the two cases,with amyloid in the stroma and the vessel walls of the lesion.The other 2 cases (cases 3 and 4) only had mild increases in the numbers of IgG4 + plasma cells without increased IgG4/IgG ratio,while amyloid deposited in the stroma only.Conclusions A subset of RDD may overlap with IgG4RD in the breast and amyloidosis could be induced in the lesion.
Keywords：Rosai-Dorfman diseaseIgG4-related diseaseAmyloidosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 725-730 )