Expression and significance of Claudin-5 in non-small cell lung carcinoma
TINA Liang
GUO Xiao-zhong
MIAO Zhi-gang
ZHANG Xin
MIAO Yu
XING Rong-ge
ZHANG Nan
Abstract：Objective To detect the expression and sig significance of Claudin-5 1n biopsy specimen and subsequent resection material of non-small cell lung carcer.Method Inmunohistochemically,Claudin-5,TTF-1,CK 5/6 and p63 were used in 105 cases of squamous cell carcinoma,64 cases of adenocarcinoma,and 32 cases of non-small cell lung cancer whose final diagnosis was decided with the subsequent resection material.The specificity,sensitivity,and positive and negative predictive values were calculated for each marker.Results The expression of Claudin-5 and TTF-1 in the lung adenocarcinoma were higher than the lung squamous cell carcinoma.CK5/6 and P63 in the the lung squamous cell carcinoma were higher than lung adenocarcinoma.There were no significant differences in the expression of the four indexes between biopsy and postoperative resection (P ＞ 0.05).No statistically difference was found between the sensitivity of immunohistochemical markers (P ＞ 0.05),the specificity of Claudin-5,TTF-1 and CK5/6 was higher than p63 (P ＜ 0.05).Conclusion Claudin-5,TTF-1,CK5/6 and P63 expression has important values in distinguishing between adenocarcinoma and squamous cell carcinoma.
Keywords：NSCLCclaudin-5TTF-1CK5/6p63Immunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 693-696 )