Diagnostic value of cytopathology in pseudomyxoma peritonei
LU Yi-yan
QI Chang-hai
LI Fang
HOU Fang
HAO Zhi-hong
PANG Shao-jun
ZHAI Xi-chao
CHEN Feng
Abstract：Objective To explore the diagnostic value of serous cavity effusion cytology in pseudomyxoma peritonei.Methods 39 cases of serous cavity effusion were processed through centrifugation,and then the samples were smeared,paraffin-embedded,HE staining and immunohistochemical staining.Results The positive rate of the paraffin-embedded block was higher than that of smeared,and the cytological morphology could be classified by 2-level,according to the histological morphological criteria:low-grade cells were arranged in single row,cell nuclei located at the base,withnot marked atypia.In the high-grade cells,nuclei were irregularly arranged with significant atypia.Some of the cells were arranged in irregular mosaic cell clusters,the size of the nucleus was different,the chromatin was rough,atypia and mucus secretion was seen in the cytoplasm in individual cells and in the background.Immunohistochemical results of paraffin-embedded block showed enterogenous sign:CK7,CK20 +,Villin +,CDX-2 +,MUC-2 +,consistent with histology.Conclusion Cytologic examination of serous effusion is valuable in preoperative diagnosis of pseudomyxoma peritonei.In addition to traditional smear,paraffin-embedded blocks are necessary to define properties and sources of pseudomyxoma peritonei.The morphological of cytological 2-grade classification is coincident with histological changes.It can provide reference for the choice of intraoperative treatment plan,and provide diagnosis for inoperable patients.
Keywords：Pseudomyxoma peritoneiSerous cavity effusionCytopathologyClassification
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 689-692 )