Differential diagnosis significance of Pax8, Ck7 and Ck20 in primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract
GUO Cun-cun
LIU Hong-sheng
TANG Zheng-hua
QIANG Xian
GE Su-mei
XING Bao-ling
Abstract：Objective To investigate the differential diagnosis significance of Pax8,CK7 and CK20 in primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract.Methods Immunohistochemical study for Ck7,Ck20 and Pax8 was carried out in 61 cases of primary ovarian mucinous tumors and 17 cases of metastatic ovarian mucinous adenocarcinoma from digestive tract.Results The expression differences of CK7 and Pax8 in primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract were statistically significant (P ＜ 0.001),but there was no statistically significant in expression of CK20 (P ＞ 0.05).The expression of CK7 +/CK20 -in primary ovarian mucinous tumors was significantly higer than that in metastatic ovarian mucinous adenocarcinoma from digestive tract (P ＜ 0.05),and the expression of CK7-/CK20 + in primary ovarian mucinous tumors was significantly lower than that in metastatic ovarian mucinous adenocarcinoma from digestive tract (P ＜ 0.001),while there were no statistically significant differences in expression of CK7 +/CK20 + and CK7-/CK20-(P ＞ 0.05).The expression difference of CK7 +/CK20-/Pax8 + in primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract was statistically significant (P ＜ 0.05).The sensitivity,specificity and areas under Roc curve(AUC) of CK7 +/CK20-immunophenotype for differential diagnosis of primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract were 0.6471,0.8361 and 0.7941,the immunophenotype CK7 +/CK20-/ Pax8 + had a sensitivity of 0.7647,a specificity of 0.8033 and AUC of 0.8664.Conclusion A panel of immunohistochemical markers Pax8,CK7 and CK20 could improve the sensitivity and AUC of the differential diagnosis of primary ovarian mucinous tumors and metastatic ovarian mucinous adenocarcinoma from digestive tract,with increased specificity.Pax8 is considered as an useful adjunct in this respect.
Keywords：Ovarian mucinous neoplasmPrimaryMetastaticPax8CK7CK20
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 674-679 )