Clinincopathologic characteristics of heterotopic mesenteric ossification
NIE Yan-hong
WANG Hong-xia
ZHAO Yong-gang
CHEN Hao
Abstract：Objective To investigate the clinincopathologic features,diagnosis and differential diagnosis of heterotopic mesenteric ossification (HMO).Methods The clinical features,histopathology and immunophenotype of 1 case of heterotopic mesenteric ossification were analyzed,retrospectively and relevant literatures were reviewed.Results Patients had previous abdominal surgery and trauma history,with bowel obstruction being the most common clinical features.Grossly,the lesions were fibrous adhesions of the small bowels,and mesentery of bowel had a firm and stiff plaque.Microscopical characteristics were similar to that of myositis ossificans,with the tumor containing mainly spindle fibroblasts/myofibroblasts,bone,bone-like matrix,adipose tissue and a small amount of cartilage tissue.Mitosis was occasionally observed with no pathological fission,and inflammation and fat necrosis were often present.Immunohistochemically,SMA,Calponin,desmin were positive in spindle cells and there were some CD68-positive histiocytes within the fat necrosis but the proliferating index labeled by Ki-67 in spindle cells was very low.Conclusion Heterotopic mesenteric ossification is a rare pseudosarcomatous reactive process that may be mistook for extraskeletal osteosarcoma,and confirmed diagnosis should be made after a comprehensive analysis of clinical history,pathological histology and the immune phenotype.
Keywords：Heterotopic ossificationMesenteryClinincopathologic featuresDifferential diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 670-673,683 )