Malignant peripheral nerve sheath tumor arising from ganglioneuroma: a clinicopathological analysis and review of the literature
TAN Li-shan
CHEN Zhi-hui
CHEN Yu-ying
WU Li-qi
MEI Kai-yong
Abstract：Object This report observed the microscopical histology of a malignant peripheral nerve sheath tumor arising from a ganglioneuroma (MPNST ex ganglioneuroma),and to explore the diagnosis and differential diagnosis with review the literature.Methods Combined with the clinical and imaging data of a malignant peripheral nerve sheath tumor arising from a ganglioneuroma (MPNST ex ganglioneuroma) in thoracic cavity,we studied the microscopical histology,immunohistochemical staining,and reviewed the previously literatures.Results Microscopically,the tumor had typical components of the ganglioneuroma,and was seen transforming into MPNST.Immunohistochemically,the tumor components were positive for vimentin,S-100 and CD56,negative for SMA,GFAP,EMA,CK,NF,CD34,Desmin,Syn,MyoD1,and myogenin.Conclusion Despite of rarity,the MPNST can arise from the ganglioneuroma.We should observe the microscopical histology and Immunohistochemical staining for the diagnosis and differential diagnosis.
Keywords：Malignant peripheral nerve sheath tumorGanglioneuromaPathology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 661-664 )