Clinicopathological characteristics of primary breast diffuse large B-cell lymphoma
ZHANG Jing
SUN Jian
LUO Yu-feng
LING Qing
LIANG Zhi-yong
Abstract：Objective To investigate the clinicopathological characteristics of primary breast diffuse large B-cell lymphoma.Methods The clinicopathological features of 12 cases of breast diffuse large B-cell lymphoma were retrospectively reviewed,with immunohistochemical study,in situ hybridization and B-cell receptor gene rearrangement analysis.Results All of the 12 patients were female,the age of onset from 22 to 77 years,with average 50.4 years.Twelve patients showed unilateral breast masses (6 cases involved left breast,and 6 cases were in right breast).Histologically,tumor cells were large to medium-sized which characterized as diffuse infiltration between the lobules of mammary gland,around the duct,interstitial and fat tissue.All of the 12 cases were DLBCL of the non special type,which expressed CD20 and CD79α.The immunophenotype showed 8 cases were of non-GCB,4 cases were of GCB type,5 cases expressed MYC and Bcl-2 and/or Bcl-6.Ki-67 index were from 70％ to 90％.Epstein-Barr virus (EBV) infection was not detected in lymphoma cells of all cases by in situ hybridization.Using BIOMED-2 multiplex polymerase chain reaction tubes,12 cases clonal IGH,6 cases IGK and 1 cases IGL gene rearrangements were detected.Conclusions Primary breast diffuse large B cell lymphoma is a rare entity,which has a unique clinicopathological characteristics,with high proliferative activity,and most of cases show a non germinal center B cell phenotype.
Keywords：Breast lymphomaDiffuse large B-cell lymphomaClinicopathological characteristicsGene rearrangement
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 641-646 )