Clinicopathological characteristics of ovarian steroid cell tumor: report of 19 cases

WANG Jing; WU Huan-wen; LIANG Zhi-yong

doi:10.3969/j.issn.1007-8096.2017.08.001

Abstract：Objective To explore the clinicopathological characteristics,immune profile,treatment and prognosis of ovarian steroid cell tumor (SCT).Methods 19 cases of ovarian SCT were studied with histological observation and immunohistochemical staining,and analyzed with review of literature.Results The patients,averaged 41 years old,were generally presented with virulism.The tumors measured 3-160 mm in size.Hitologically,they were categorized into SCT-NOS and Leydig cell tumor.Cells with abundant lipid-rich cytoplasm were more commonly seen in SCT-NOS,resembling adrenal zona glomerulosa and zona fasciculate.Leydig cell tumors were mainly composed of eosinophilic cells,with cytoplasmic Reinke crystals or eosinophilic inclusions.Clustering of nuclei alternated with nuclear-free zone,and fibrinoid necrosis of blood vessel wall could be seen.Immunohistochemically,most tumors showed positive staining ofα-inhibin,calretinin,CD99 and Melan-A.Focally positive staining of AE1/AE3 and Syn was detected in one case,respectively.Only 1 case showed intraperitoneal metastases and relapsing.All patients were in the state of disease-free survival after surgery and a follow-up averaged 24 months.Conclusion The diagnosis of ovarian SCT is based on distinctive histopathology and immunohistochemical staining profile.The tumor presents good prognosis,albeit a few cases of intraperitoneal metastases and relapsing.