Clinicopathologic features of uterine tumor resembling ovarian sex-cord tumor
LIU Xiao-gang
TAO Xiang
LIU Yan
ZHANG Xin-peng
XUE Hui-zhong
KONG Ling-hong
CAI Hui
Abstract：Objective To investigate the clinicopathologic features of uterine tumor resembling ovarian sex-cord tumor (UTROST) to avoid misdiagnosis.Methods The clinical findings,morphologic features,immunohistochemical markers and gene mutation analysis in one case of UTROSCT were studied.Results A 20-year-old student presented with abnormal vaginal bleeding for one year and anemia for three months.The tumor was about 12 cm in maximum diameter with yellow appearance.Microscopically,the tumor had cord,trabeculae,nest,solid,and poseudo-adenoid pattern;the tumor cells were epithelioid partly with foam-like cytoplasm,prominent nucleoli and mitotic figures (3/10 HPF).The immunohistochemical staining showed that tumor cells were positive for CK,CK8,CK19,vimentin,CD99,bcl-2,AR,ER and PR,focal positive for calretinin and CD56,but negative for Inhibin-α,Melan-A,WT-1,FOXL2,SF-1,S-100,PAX-8,CD10,CK7,CK20,CK5,CK14,CK34βE12,p16,EMA,HMB45,SMA,Desmin,Calponin,S-100,CD117,CD34,FLI-1,MC,CD133,CD44,CgA and Syn;P53 showed wild type and Ki-67 index number was about 5 percent.FOXL2 and DICER1 mutation were absent.The patient was alive after follow up for 4 months after hysterectomy.Conclusions UTROSCT is a very rare tumor and FOXL2 and DICER1 mutation might be absent.The definite diagnosis depends on morphological observation and immunohistochemical analysis.
Keywords：Uterine tumor resembling ovarian sex cord tumorImmunophenotypeGene mutation
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 527-531 )