Clinicopathologic features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
TANG Ying-zi
YU Xiao-dong
TANG Ying-cheng
WANG Xue
GAO Yun-jing
Abstract：Objective To explore the clinicopathologic features of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma.Methods The clinicopathologic features,imaging and immunohistoehemistry were analyzed in a case of thyroid-like low-grade nasopharyngeal adenocarcinoma with review of the literature.Results The patient was a 22-year-old man complaining of nasal obstruction.Laryngoscopic study identified a spherical mass located on the nasopharyngeal region.Histologically,the papillae were complex and tightly packed with hyalinized fibrovascular cores and lined by columnar and pseudostratified cells with intervening spindle-shaped cells.Both cell types had round to oval vesicular nuclei and mildly eosinophilic cytoplasm.The tumour cells were strongly and diffusely positive for TTF-1,CK7,CK5/6,CK19,EMA and vimentin,but negative for CK20,S-100,SMA,PAS and Tg.Conclusion Thyroid-like lowgrade nasopharyngeal papillary adenocarcinoma is an extremely rare neoplasm in the nasopharynx which typically occurs in adolescents.These tumours are amenable to surgical resection and have an excellent prognosis.
Keywords：NasopharynxThyroid-like low-grade nasopharyngeal papillary adenocarcinoma (LGNPPA)Pathological features
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 503-506 )