Clinicopathologic features of medullary carcinoma of the colon: a report of 2 cases
CHEN Yu-ling
FAN Xiang
WANG Guo-qing
DING Fen-gan
ZHAO Xue-han
ZHANG Li-hua
Abstract：Objective To study the clinicopathological features,molecular characteristics,differential diagnosis of medullary carcinoma of the colon.Methods Two cases of poorly differentiated large bowel carcinomas were identified as medullary carcinoma.Clinical data,histological appearance,immunophenotype,molecular characteristics and EBEV status were observed,and the related literatures were reviewed.Results Two cases of medullary carcinoma were old women,aged 81 and 87 years,respectively.Both tumors were located in the ileocecal region.Microscopically,the neoplastic cells showed a solid nested,organoid and trabecular growth pattern.Tumors often contained higher amounts of tumor-infiltrating lymphocytes as a distinguishing feature.Tumor cells were large round to oval nuclei,with amphophilic nucleoli,and vesicular chromatin.Immunohistochemical reactions were negative for CDX2 and CK20.Mismatch repair protein MLH1/ PMS2 was negative,and MSH2/MSH6 positive.The tumor showed B-RAF gene V600E mutation and negative EBER in tumor cells.Conclusions Medullary carcinoma of the colon is a rare and unique subtype of colorectal carcinoma,which represents a distinct pathologic entity,with specific histological appearance and peculiar clinical and genetic features.It needs to be classified separately from other poorly differentiated colorectal carcinomas,which has better survival as compared with others colorectal carcinoma.
Keywords：Colorectal carcinomaMedullary carcinomaLymphoid stromaClinical pathology
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 431-434 )