Primary epithelioid angiosarcoma of bone: a clinicopathological study of six cases
FENG Xiao
SHI Qian-yun
ZHANG Ru-song
YU Bo
RAO Qiu
SHI Qun-li
ZHANG Xin-hua
Abstract：Objective To explore the clinicopathological features,diagnosis and differential diagnosis of primary epithelioid angiosarcoma of bone (PEAB).Methods By analysis of the clinical data in 6 cases of PEAB,the histological morphology and immunohistochemical characteristics of PEAB were studied,and their relevant literatures were reviewed.Results Of 6 PEAB patients,there were 5 males and 1 female and median age was 46.5 years.There were 2 cases in the femur,2 cases in the humerus,1 case in the tibia,1 case in the hip bone.The symptom of these cases were localized pain.Histologically,the tumor consisted of solid sheets of large epithelioid cells.Vasoformative structures ranged from well-formed vessel to slit-like anastomosing vascular channels were seen in local region.Vacuoles containing red blood cells were also noted in some tumor cells.Immunohistochemically,the tumor cells were stained positive for CD31,vimentin,partly postive for ERG,Fli-1 and CKpan.Of the 6 cases,follow-up data were available for 4 patients,2 of them were died after surgical resection;the remaining two were survival.Conclusions Primary epithelioid angiosarcoma of bone is very rare,and it should be different from metastatic carcinoma.An accurate diagnosis is based on clinical manifetations,imaging data and immunohistochemical staining.
Keywords：BoneEpithelioid angiosarcomaImmunohistochemistryDifferential diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 415-418 )