Clinicopathologic features of adrenal cortical carcinoma
WANG Ling-ling
DU Xue-mei
CHANG Hong
SHEN Bing
ZHANG Jian-ying
GAO Ying
Abstract：Objective To explore the clinicopathologic characteristics,diagnosis and differential diagnosis,prognosis and treatment of adrenal cortical carcinoma.Methods Clinical data,pathological changes and immunohistochemical staining were observed in 6 patients with adrenal cortical carcinoma.Results There were six cases including four women and two men,aged from 23 to 60 years,average age of 53 years;3 cases were functioning and 3 cases were nonfunctioning.Microscopic examination showed that the tumor cells were polygonal,rich and eosinophilic cytoplasm,and coarse granular nuclear chromatin;tumor cells arranged in nests or sheets and invaded into the capsule.Immunohistochemical staining showed that tumor cells positively expressed Melan-A,inhibin-α and p53,negatively expressed Cg-A;two of them negatively expressed MSH2 and MSH6,and positively expressed MLH1 and PMS2.Conclusion The diagnosis of adrenocortical carcinoma is based on clinical features and main histopathologic architectural changes.Immumohistochemical staining may be helpful in diagnosis and differential diagnosis of adrenocortical carcinoma.It is essential to enhance awareness of pathological characteristics of adrenal cortical carcinoma to avoid misdiagnosis.
Keywords：Adrenocortical carcinomaImmunohistochemistryDiagnosisDifferential
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 354-357,362 )