Value of PHH3 in the histologic grading of breast invasive ductual carcinoma and its clinical significance
LI Ming
ZHOU Pei-pei
WANG Jin-song
HUANG Wen-bin
Abstract：Objective To study the expression of phosphohistone H3 (PHH3) in breast invasive ductual carcinoma,and to explore the value of PHH3 in the histologic grading of breast invasive ductual carcinoma and its clinical significance.Methods Immunohistochemical EnVision staining was used to detect the expression of PHH3 in 85 cases of invasive carcinoma of breast.Results There was a positive correlation between PHH3-1abeled mitotic index and HE-stained mitotic index.Based on PHH3-1abeled mitotic index,it was shifted from grade Ⅰ to grade Ⅱ in one case,and from grade Ⅱ to grade Ⅲ in 4 cases.High PHH3-1abeled mitotic index was related to histologic grade and lymph node metastasis (P ＜0.05),but unrelated to age,location and size of tumor (P ＞ 0.05).Conclusion PHH3 can serve as a promising marker for specific detection of mitotic figures and may improve the accuracy of the histologic grading of breast invasive carcinoma,which may provide the guidance for clinical treatment.
Keywords：Breast neoplasmInvasive ductual carcinomaPHH3Histologic gradingImmunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 342-345 )