Clinicopathological characteristics and prognosis of primary central nervous system lymphoma: report of 79 cases
HU Pei-zhu
LI Meng-meng
ZHAO Wu-gan
LI Chen-fei
WANG Guan-nan
ZHANG Dan-dan
ZHANG Yan-ping
LI Wen-cai
Abstract：Objective To study the clinicopathological characteristics and prognostic factors of primary central nervous system lymphoma (PCNSL).Methods A total of 79 cases of PCNSL were collected by surgical removal or biopsy,and then pathological characteristics and immunophenotype were observed by using HE staining and EnVision immunohistochemistry.Univariate analysis was used to study the relationships between prognosis and the factors including age,site,number of lesions,IPI score and immune subtype.Then we used the Cox regression model to analyze multivariate influence factors.Results The most common type of PCNSL was diffuse large B cell lymphoma (DLBCL)and the immunophenotype was mainly non-GCB type.Univariate analysis showed that age,IPI score and BCL-6 protein expression were releted to the prognosis (P ＜ 0.05).Multivariate analysis showed that IPI score was an independent factor (P ＜ 0.05).Conclusion PCNSL is a highly invasive cancer,with poor prognosis,and short-term mortality is high.IPI score is an independent factor.There is no significant difference in the prognosis between GCB and non-GCB subtypes of DLBCL.
Keywords：Central nervous systemLymphomaDiffuse large B cell lymphoma
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 323-326 )