p16/Ki-67 dual stain cytology and HR-HPV detection in screening CIN 2/3 diagnosed as ASCUS or LSIL
LIU Yu-yan
SHAN Jing-jun
DONG Li
WU You-tian
HUANG Ying
Abstract：Purpose To investigate the diagnostic value of p16/Ki-67dual stain cytology and HR-HPV detection of cervical precancer as a novel option for cervical lesions screening.Methods A total of 295 cases diagnosed as ASCUS and LSIL were selected between 2014 December and 2016 July from the First Hospital of Harbin.Double staining of p16/ Ki-67 cytology,HPV testing,vaginal biopsy,biopsy and pathological examination were applicated,p16/Ki-67dual stain cytology was compared with that HPV detection of sensitivity and specificity.Results The positive rate of p16/Ki-67 dual stain cytology were 37.42％ and 36.36％ in ASCUS and LSIL,respectively.The positive rates of CIN 2/3 were 25.77％ and 25.76％ from biopsy,both having a high rate of compliance.The sensitivity of the p16/Ki-57 test for detecting CIN 2/3 was 83.33％,and the specificity was 78.51％.The sensitivity of HPV test for detecting CIN 2/3 was 83.33％,and the specificity was 78.51％.Conclusions The double staining of P16/Ki-67 is similar sensitivity to that of HPV,and the specificity of the shunt is significantly increased.The coincidence rate between p16/Ki-67 cytology and biopsy is higher.p16/Ki-67 double stain detection can effectively split the high grade cervical lesions in TCT and improve the accuracy of cervical cancer screening.
Keywords：p16/Ki-67 dual stain cytologyHPVCervical cancer screening
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 278-280,287 )