Expression of TTF-1 and galectin-3 in the diseases of sellar region
HUO Zhen
ZHOU Liang-rui
LUO Yu-feng
LIANG Zhi-yong
Abstract：Objective To explore the immunohistochemical expression of TTF-1 and galectin-3 in the diseases of sellar region.Methods TTF-1 and galectin-3 expression was studied in 48 case of surgically resected primary diseases of sellar region by immunohistochemistry,including pituicytomas,spindle cell oncocytomas,glanular cell tumours,pilocytic astrocytomas,menigiomas,pituitary adenomas and schwannomas.Adenohypophyses and neurohypophyses were also investigated.Results TTF-1 was positive in pituicytomas (6/6),spindle cell oncocytomas (2/2),glanular cell tumours (2/2),and neurohypophyses (10/10),but completely negative in pilocytic astrocytomas (0/4),menigiomas (0/6),schwannomas (0/2),pituitary adenomas (0/10),germinomas (0/6),Rathke's cleft cyst (0/5),and adenohypophyses (0/10).TTF-1 was focal positive in craniopharyngiomas (2/5).galectin-3 was positive in all cases except germinomas and some pituitary adenomas.Conclusion TTF-1 is only positive in pituicytomas,spindle cell oncocytomas,glanular cell tumoursa and neurohypophyses,indicating the origin of neurohypophyse,and it can helpful for making differential diagnosis from other sellar region diseases.Galectin-3 is of little use in the differential diagnosis of sellar region diseases because of expression ubiquitious.
Keywords：Sellar regionTTF-1Galectin-3Immunohistochemistry
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 210-214 )