Ectopic thyroid tissue in the adrenal gland: a clinicopathologic study combined with literature review
GAO Min
ZHANG Shi-hao
LIAO Yu-ting
WEN Yong-qin
HE Jian-fang
ZHAO Dong-hui
LIANG Yuan-qiu
Abstract：Objective To investigate the clinicopathological characteristics,and the possible occurrence mechanism of ectopic thyroid in the adrenal gland.Methods We report a case of of ectopic thyroid in the adrenal gland in a 31-year-old woman.Pathologic analyses including histomorphologic,immunohistochemical and molecular studies were performed to evaluate the clinicopathological features of ectopic thyroid in the adrenal gland and review of the literature.Results The surgical specimen showed a cyst-solid mass in the adrenal gland.The cystic cavity was filled with eosinophilic,colloid-like substance with a small amount of reactive foam cells.The cyst wall included many follicles that was surrounded by a monolayer of follicular cells,occupied by colloid,intermingled with adrenal tissue.There were no nuclear atypia,grooves or cytoplasmic pseudo-inclusions.Follicular cells were immunohistochemically positive for CK,TPO,Tg,TTF-1 and negative for CK19,galectin-3,CT,Syn and CgA.Furthermore,molecular analysis about BRAF V600E 及 KRAS genes did not identify mutations.Conclusion Ectopic thyroid is a congenital developmental defect,ectopic thyroid in the adrenal gland is extremely rare,the mechanism is unknown and warrants further study.
Keywords：Ectopic thyroidAdrenal glandOccurrence mechanism
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 198-201 )