Clinicopathological features of primary hepatic neuroendocrine carcinoma
ZHENG Zeng-guang
SUN Wen-yong
Abstract：Objective To explore the clinicopathological features,image changes,differential diagnosis and prognosis of primary hepatic neuroendocrine carcinoma (PHNEC).Methods We summarized the clinicopathological data of two patients having diagnosed as PHNEC and reviewed the related literatures.Results Two patients presented with different degrees of abdominal pain and disorder of liver function.Meanwhile,image showed that liver had a huge tumor.The tumor was composed of a diffuse proliferation of short-spindle-shaped or lymphocyte-shaped tumor cell with abundant blood vessels.There were obvious necrosis and mitosis.The tumor cells expressed Syn,CHG-A and CD56;Two patients had the treatment of TACE (transcatheter arterial chemoembolization,TACE),one of them lost for follow-up,the other one died after 6.5 months.Conclusions PHNEC is a rare neuroendocrine tumor,insidious onset,early diagnosis is difficult.Disease diagnosis depends on morphological observation of pathology and immunohistochemistry.Due to the high degree of malignancy of the tumor,for patients with unresectable tumor,TACE can contribute to improve the survival time of them.
Keywords：LiverNeuroendocrine carcinomaPathological diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 182-185 )