Adrenal cortical carcinoma: a study of 3 cases and review of literature
LIU Dong-mei
SHENG Yv-jun
HUANG Cai-hong
Abstract：Objective To analyze the clinical and pathologic features of adrenal cortical carcinoma.Metheds Three cases of adrenal cortical carcinoma were studied with histology and immunohistochemical staining,and its clinical and pathological findings were further analyzed with review of literature.Results Among 3 cases,2 were males and one was female with mean age of 53 years (ranged 40-62 years).The 3 cases were all located at the left adrenal gland.In all 3 cases,2 cases had endocrine clinical manifestation of Cushing's syndrome,the other dit not.Microscopically,the tumer cells arranged in nests and flake with variant size,prominent unclear atypia.The tumor invasion of capsule and blood vessels was noted.Immunophenotypically,the tumer cells were positive for Syn and NSE.Conclusion Adrenal cortical carcinoma is arare malignant neoplasm.The clinical and radiologic findings must be known for differential diagnosis from other adrenal tumors.Adrenal cortical carcinoma has a worse prognosis,and radical surgery is the preferred treatment for this disease.
Keywords：Adrenal cortical carcinomaClinicopathologyDiagnosisDifferential diagnosis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 174-177 )