Mantle cell lymphoma: a clinicopathological study of 10 cases

SONG Hong-jie; QIAO Hai-guo; ZHOU You

doi:10.3969/j.issn.1007-8096.2017.03.001

Abstract：Purpose To discuss the clinical pathological features,diagnosis and differential diagnosis,prognosis of mantle cell lymphoma (MCL).Methods 10 cases of MCL were collected,their clinical pathological characteristics and immunophenotypes were also observed,and the prognosis was followed up.Results Of the 10 cases of MCL,7 were men and 3 were women,and they were all of the middle-aged and old people.The performance of the tumor was that the structure of the lymph node disappeared in different degrees,including diffused or dim nodular proliferation.There was phenomenon of scattered starry sky and small blood vessels between cells were clearly visible with hyaline degeneration and mild rigidification.Most of the MCL belonged to the classial type.It was made up of centrocyte-like B cells,whose nuclei were monomorphic,irregular and small to medium in size,including diffused or nodular proliferation.It was one of the small B cell lymphoma.The immunohistochemistry showed positive CD20 (10/10),CD79α (10/10),Pax-5 (10/10),CD5 (9/10),bcl-2 (10/10),cyclinD1(10/10) and SOX11 (10/10).The Ki-67 was 20％-50％ positive.Follow-up results showed that three people of the ten cases survived less than three years,three people survived three to five years,one person survived more than five years(87 months),and the rest three people were following up.Conclusion MCL is one of the few types of B cells lymphoma,which features both indolent and aggressive non-Hodgkin's lymphoma.It is dominated by elderly male patients and lymph nodes are most frequently involved,with higher clinical stages and poorer prognosis.To be familiar with clinical pathological features and immunophenotypes is useful to improve the differential diagnosis with other typs of lymphoma.