Analysis of the therapeutic effect of hyperbaric oxygen combined with EEG biomimetic electrical stimulation on delayed encephalopathy after acute carbon monoxide poisoning
DU Peng
Abstract：Objective:To analyze the clinical efficacy of hyperbaric oxygen combined with EEG biomimetic electrical stimulation in the treatment of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).Methods:From January 2023 to December 2024,76 patients with DEACMP who visited the hospital consecutively were grouped according to the dynamic randomization method.The conventional group(n=38)received hyperbaric oxygen therapy,and the combination group(n=38)received EEG biomimetic electrical stimulation therapy on the basis of the conventional group.The clinical efficacy,Mini-Mental State Examination(MMSE)score,Hasegawa Dementia Scale(HDS)score,and nerve damage indicators[neuron-specific enolase(NSE),S100 calcium-binding protein β(S-100β),and creatine kinase BB(CK-BB)]were compared between the two groups.Results:Compared with the conventional group(73.68%),the combination group(94.74%)had a better clinical efficacy(P<0.05).Compared with the conventional group,the combination group had higher MMSE scores and HDS scores after treatment(P<0.05).Compared with the conventional group,the combination group had lower levels of serum NSE,S-100 β,and CK-BB after treatment(P<0.05).Conclusion:Hyperbaric oxygen combined with EEG biomimetic electrical stimulation can effectively improve cognitive function and reduce nerve damage in DEACMP patients,with significant effects.
Keywords：hyperbaric oxygenEEG biomimetic electrical stimulationacute carbon monoxide poisoningdelayed encephalopathyclinical efficacy
Publication Date：2025-08-28
Online Publishing Date：2025-09-26(First online date of this platform, not the publication date of the document)
Pages：4( 47-50 )