Effect of medical carbon dioxide pneumoperitoneum pressure regulation on recovery after laparoscopic partial hepatectomy

YAO Chanjuan

doi:10.3969/j.issn.2096-2525.2025.03.007

Abstract：Objective:To investigate the effects of different medical carbon dioxide pneumoperitoneum pressures on postoperative pain,metabolic indicators,and inflammatory responses in patients undergoing laparoscopic partial hepatectomy,and to clarify its application value in perioperative nursing interventions.Methods:A total of 120 patients undergoing laparoscopic left or right partial hepatectomy were selected and divided into low-pressure group(8 mmHg),medium-pressure group(12 mmHg),high-pressure group(15 mmHg),and blank control group according to different pneumoperitoneum pressures.Postoperative indicators including Visual Analog Scale(VAS)scores,arterial partial pressure of carbon dioxide(PaCO₂),blood lactate(Lac),and tumor necrosis factor-α(TNF-α)levels were collected within 24 h and compared among groups.Results:The high-pressure group showed significantly higher VAS scores,PaCO₂,Lac,and TNF-α levels than the other three groups(P<0.05),followed by the medium-pressure group,while the low-pressure group and the blank control group showed no significant difference.Gastrointestinal recovery was also delayed in the high-pressure group,as evidenced by prolonged time to bowel sound recovery and first flatus.Conclusion:High pneumoperitoneum pressure has a negative effect on postoperative metabolic burden and inflammatory response,leading to enhanced discomfort and delayed recovery.The setting of medium and low pneumoperitoneum pressure can effectively relieve postoperative pain,lower CO₂ accumulation,and promote gastrointestinal recovery,making them preferable for perioperative management in laparoscopic liver surgery.