Analysis of risk factors for bloodstream infections during ECMO treatment in patients with respiratory failure
HUANG Kang
LYU Jianlei
LIU Min
DAI Yao
Abstract：Objective:To explore the risk factors for bloodstream infections during extracorporeal membrane oxygenation(ECMO)treatment in patients with respiratory failure.Methods:From March 2020 to February 2024,60 patients with respiratory failure undergoing ECMO admitted to our hospital were observed for the occurrence of bloodstream infections within 24 h from ECMO initiation to 48 h after ECMO withdrawal.A total of 18 patients with respiratory failure who developed bloodstream infections were in the infected group,while the remaining 42 patients were in the uninfected group.Blood cultures,platelet transfusion volume,suspended red blood cell transfusion volume,Murrary lung injury score,and Sequential Organ Failure Assessment(SOFA)score were observed.Results:There was no significant difference between the two groups in the proportion of autoimmune diseases and diabetes,age,ECMO successful weaning ratio,ECMO support time,gender,and SOFA score(P>0.05).The Murrary lung injury score in the infected group was higher than that in the uninfected group(P<0.05).During ECMO treatment,the platelet transfusion volume and suspended red blood cell transfusion volume in the infected group were higher than those in the uninfected group(P<0.05).Multivariate logistic regression analysis showed that the Murrary lung injury score(OR=1.694,P=0.000),platelet transfusion volume(OR=1.230,P=0.013),and suspended red blood cell transfusion volume(OR=1.145,P=0.001)were found.Conclusion:Acinetobacter baumannii and Klebsiella pneumoniae are the main pathogens causing bloodstream infections during ECMO treatment in patients with respiratory failure.Excessive platelet transfusion volume and suspended red blood cell transfusion volume,as well as elevated Murrary lung injury score,are independent risk factors for bloodstream infections during ECMO treatment.
Keywords：respiratory failurebloodstream infectionextracorporeal membrane oxygenationblood culture
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 27-29 )