Advance of mesenchymal stem cell-derived exosome miRNA in the treatment of inflammatory diseases by regulating macrophage polarization
REN Yiqian
WANG Yao
LIU Xianning
Abstract：As an important part of innate immunity,the balance between M1/M2 macrophages is involved in immunoinflammatory regulation,tissue repair and regeneration.In recent years,it has been found that the immune regulation mediated by mesenchymal stem cell-derived exosomes(MSC-Exos)is closely related to the function regulation of macrophages.MSC-Exos inhibit inflammation and promote tissue repair by regulating the polarization of M1 macrophages to M2 macrophages,and this regulation is partly mediated by the bioactive factor miRNA contained in MSC-Exos,which is still under exploration.Furthermore,changing the expression level of MSC-Exos miRNA by preconditioning can enhance its immune regulation.This paper reviews the effects and mechanisms of MSC-Exos miRNA on macrophage polarization in the treatment of inflammatory diseases in recent years.
Keywords：mesenchymal stem cellsexosomesmacrophagesinflammation
Publication Date：2026-07-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 1087-1092 )