Impact of hyperandrogenism on endometrial receptivity in polycystic ovary syndrome and intervention mechanisms of traditional Chinese medicine
LI Mengyuan
HE Junqin
HAN Qian
Abstract：Polycystic ovary syndrome(PCOS)is a common reproductive endocrine disorder in women of reproductive age,characterized by ovulatory dysfunction and hyperandrogenism(HA),which severely affects the fertility of patients.Ovulation induction treatment can significantly improve the ovulation status of patients with PCOS,but even after ovulation is restored,many patients still cannot conceive or maintain pregnancy normally.Therefore,how to improve the endometrial receptivity(ER)of patients with PCOS is a current challenge.Many studies have shown that HA is an important cause of decreased ER in patients with PCOS,which may be closely related to abnormal hormone secretion,systemic inflammation and oxidative stress,abnormal angiogenesis and hypercoagulable state,and involves multiple pathophysiological links such as metabolic syndrome,autophagy,and ferroptosis.Traditional Chinese medicine(TCM)has outstanding effects in"regulating menstruation,promoting fertility,and ensuring fetal safety".Modern research has confirmed that TCM can improve the ER of patients with PCOS and HA through multiple pathways and targets.This study reviews the mechanism by which HA affects ER and the intervention strategies and research progress of TCM.
Keywords：polycystic ovary syndromehyperandrogenismendometrial receptivitytraditional Chinese medicine therapyinsulin resistanceinflammationoxidative stressprethrombotic state
Publication Date：2026-07-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：7( 1068-1073,1079 )