Improvement effect of Renshen Yangrong Decoction on the biological rhythm of patients with vasovagal syncope

TAO Chunlan; FANG Ye; YU Yibo

doi:10.13276/j.issn.2097-1656.2026.07.015

Abstract：Objective To explore the improvement effect of Renshen Yangrong Decoction on the biological rhythm of patients with vasovagal syncope(VVS).Methods A total of 97 VVS patients admitted to the First Affiliated Hospital of Ningbo University from January 2022 to January 2024 were selected as the research subjects and randomly divided into observation group(n=48)and control group(n=49).Propensity score matching method was used to match them in a 1 ︰1 ratio,with 45 patients in each group.The control group received conventional treatment,while the observation group was treated with Renshen Yangrong Decoction on the basis of the control group's treatment.Changes in serum electrolyte levels,hemorheology,hormone levels,and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups of patients before and after treatment.Changes in biological rhythm indicators of patients before and after treatment were compared and analyzed,and generalized estimating equation(GEE)model was used to analyze their improvement.Pearson correlation analysis was conducted,and difference-in-difference model was used to analyze the treatment efficacy of patients.Results Compared with the control group,the treatment effect of VVS in the observation group was significantly improved(P＜0.05).Compared with before treatment,the levels of standard deviation of R-R intervals(SDNN),standard deviation of the averages of NN intervals(SDANN),root mean square of successive differences(rMSSD),percentage of successive RR intervals that differ by more than 50 ms(PNN50),low frequency(LF),LF/high frequency(HF),sodium,calcium,and chlorine in both groups of patients significantly increased after 2 and 4 weeks of treatment,while the levels of HF,potassium,phosphorus,fibrinogen(Fib),low shear blood viscosity(LBV),plasma viscosity(PV),high shear blood viscosity(HBV),adrenaline(AD),prolactin(PRL),and cortisol(Cor)significantly decreased.Moreover,the changes in these indicators in the observation group were significantly greater than those in the control group(P＜0.05).Pearson correlation analysis showed that the levels of SDNN,SDANN,rMSSD,PNN50,LF,and LF/HF in patients were positively correlated with sodium,calcium,and chlorine(r＞0,P＜0.05),and negatively correlated with potassium,phosphorus,Fib,LBV,PV,HBV,AD,PRL,and Cor(r＜0,P＜0.05).HF levels were negatively correlated with sodium,calcium,and chlorine(r＜0,P＜0.05),and positively correlated with potassium,phosphorus,Fib,LBV,PV,HBV,AD,PRL,and Cor(r＞0,P＜0.05).The results of GEE model analysis showed that the improvement of SDNN,SDANN,rMSSD,PNN50,LF,HF,and LF/HF in the observation group was better than that in the control group(P＜0.05).After treatment,the scores of the main and secondary symptoms of TCM syndromes in both groups of patients were significantly lower than before treatment,and the observation group was significantly lower than the control group(P＜0.05).The results of the difference-in-difference model showed that the improvement of the main symptom score(β=-1.501,P＜0.001)and secondary symptom score(β=-6.488,P＜0.001)of the observation group was significantly better than that of the control group,and the total effective rate of the observation group(91.11％)was significantly higher than that of the control group(73.33％)after treatment.Conclusion The use of Renshen Yangrong Decoction in the treatment of VVS patients can significantly reduce their hemorheology and hormone levels,regulate serum electrolyte levels,and promote the improvement of their biological rhythms and quality of life,which can be widely applied in clinical practice.