Programmed cell death networks:a new paradigm for research and therapy in traumatic brain injury
ZHANG Jianning
SONG Xiaomeng
Abstract：Traumatic brain injury(TBI)is one of the leading causes of death and long-term disability worldwide,not only severely impairing patients' physical function and quality of life but also imposing a heavy burden on the healthcare system.Recent studies have shown that programmed cell death plays a critical role in the pathological process of secondary injury following TBI.This review systematically summarizes the distinct roles and molecular mechanisms of various forms of programmed cell death-such as apoptosis,pyroptosis,necroptosis,ferroptosis,and cuproptosis-in TBI,revealing the complex regulatory network through which they collectively influence the extent of brain tissue damage and neural functional recovery.Furthermore,it outlines current research progress and application prospects of intervention strategies targeting these forms of cell death,including signaling pathway inhibitors,protein modification regulation,and stem cell therapy.The review aims to provide a theoretical basis for further elucidating the pathogenesis of TBI and to identify future directions for developing new clinical treatment strategies and potential therapeutic targets.
Keywords：traumatic brain injurycell deathapoptosispyroptosisnecroptosisferroptosissecondary injuryneuroinflammation
Publication Date：2026-02-28
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：7( 157-163 )