Progress in diagnosis and treatment of severe autoimmune encephalitis
LI Wen
HAO Xiaofang
LI Xiaona
JIANG Wen
Abstract：Autoimmune encephalitis(AE)is a type of encephalitis that is mediated by autoimmune mechanisms.The main clinical manifestations include acute or subacute psychological and behavioral abnormalities,seizures,and cognitive impairments.At least 1/3 of AE progresses into severe AE,often accompanied by severe autonomic dysfunction,status epilepticus,or central hypoventilation syndrome,necessitating intensive care unit admission.Early immunotherapy can significantly improve the clinical symptoms of these patients and reduce the rates of disability and disease recurrence.Therefore,for severe AE,early diagnosis,early treatment,and in-depth understanding are of great significance for the treatment and prevention of the disease.This article reviews the classification,diagnosis and treatment progress,and prognosis of severe AE,aiming to provide clinicians with more help in the diagnosis and treatment of severe AE.
Keywords：encephalitisautoimmune diseasessevere diseaseprogress in diagnosis and treatment
Publication Date：2025-12-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 1718-1722 )