Analysis of factors associated with pathological upgrading following hysterectomy for atypical endometrial hyperplasia diagnosed via hysteroscopy
HE Yuanyuan
LYU Yanhong
JIN Yihua
LIU Nian
LIU Shujuan
ZHUO Na
WEI Li
Abstract：Objective To analyze the risk factors for pathological upgrading to endometrial carcinoma(EC)in patients diagnosed with atypical endometrial hyperplasia(AEH)by hysteroscopy after total hysterectomy.Methods A retrospective analysis was performed on patients who underwent total hysterectomy for AEH diagnosed by hysteroscopy in Xijing Hospital,Air Force Medical University from January 2021 to December 2023.The clinical and pathological data were collected,and univariate and multivariate logistic regression analyses were used to analyze the risk factors of AEH complicated with EC and the pathological and The Cancer Genome Atlas molecular subtyping of AEH complicated with EC.Results A total of 62 patients were included,26 of whom were pathologically upgraded to EC after total hysterectomy.Univariate logistic regression analysis showed that BMI,endometrial thickness under ultrasound,triglyceride and CA125 were the influencing factors of AEH complicated with EC.Multivariate logistic regression analysis showed that elevated triglyceride was an independent risk factor for AEH complicated with EC.The pathological type of AEH complicated with EC was endometrioid adenocarcinoma,76.92％ were highly differentiated,and 71.43％ had no specific molecular profile.Conclusion Hypertriglyceridemia is an independent risk factor for AEH complicated with EC.
Keywords：atypical endometrial hyperplasiaendometrial carcinomapathological upgradingThe Cancer Genome Atlas
Publication Date：2025-12-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 1658-1663 )