Mechanism of genistein in treating periodontitis based on network pharmacology and bioinformatics analysis
LU Jin
LI Zhinuo
LI Zhaohui
LI Yujie
HONG Peifeng
YANG Xuechao
NIE Min
Abstract：Objective To explore the potential targets and molecular mechanisms of genistein in the treatment of periodontitis based on network pharmacology,molecular docking technology and bioinformatics analysis.Methods A variety of databases were used to predict the targets of genistein and periodontitis,and GO functional analysis and KEGG enrichment analysis were conducted.The protein-protein interaction network of genistein-periodontitis was plotted using STRING database,and the top 10 key targets were obtained using Cytoscape software.The key targets of genistein in the treatment of periodontitis were analyzed by molecular docking technology.The key cell types on which genistein might act were analyzed using a periodontal single-cell sequencing dataset.Results A total of 731 periodontitis-related disease targets and 89 genistein targets were obtained from the database,and 27 key targets were screened.GO and KEGG pathway enrichment analysis showed that genistein might play a therapeutic role by regulating signaling pathways such as estrogen and serine-type endopeptidase.The results of molecular docking analysis showed that genistein had good binding potential with multiple targets.Conclusion This study explores the potential targets and mechanisms of genistein in the treatment of periodontitis,providing a reference for promoting drug research and development and application.
Keywords：genisteinperiodontitisnetwork pharmacologymolecular dockingbioinformatics analysismechanism of actiontargetsinflammatory reaction
Publication Date：2025-10-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 1275-1279 )