Effect of triple compound inhalation aerosol on chronic obstructive pulmonary disease and its influence on pulmonary function,blood gas and inflammation
HE Ting
ZHAO Qingqing
XU Cunlai
Abstract：Objective To observe the effect of triple compound inhalation aerosol in the treatment of chronic obstructive pulmonary disease(COPD)and its influence on pulmonary function,blood gas and inflammation.Methods A total of 158 patients with COPD admitted to the First Affiliated Hospital of Lishui University were retrospectively studied from June 2022 to June 2024.According to different therapeutic drugs,the above patients were divided into conventional group(n=76,respiratory function exercise+budesonide nasal spray+formoterol fumarate inhalation solution)and experimental group(n=82,respiratory function exercise+budesonide inhalation aerosol).Both groups were treated for 3 months,and the efficacy,pulmonary function,blood gas parameters,inflammatory parameters and adverse reactions were compared between the two groups.Results ①After treatment,the total effective rate in experimental group(95.12％)was higher than that in conventional group(85.53％)(P＜0.05).② After treatment,the pulmonary function indicators such as forced expiratory volume in the first second[(1.74±0.35)L],maximum voluntary ventilation[(70.55±6.73)L/min],forced vital capacity[(2.91±0.71)L]and 6-minute walk test[(349.57±15.03)m]in experimental group were all higher than those in conventional group[(1.56±0.33)L,(65.92±6.80)L/min,(2.66±0.69)L and(330.61±14.99)m](P＜0.05).③After treatment,the oxygen saturation[(91.34±4.57)％]and arterial partial pressure of oxygen[(84.37±5.72)mmHg]in experimental group were higher than those in conventional group[(89.55±4.50)％and(81.66±5.84)mmHg],while the partial pressure of carbon dioxide[(33.16±4.21)mmHg]in experimental group was lower than that in conventional group[(35.78±4.19)mmHg](P＜0.05).④After treatment,the levels of inflammatory parameters such as interleukin-6[(19.66±3.84)ng/L],eosinophils[(1.16±0.30)× 109/L]and C-reactive protein[(10.27±2.10)mg/L]in experimental group were lower than those in conventional group[(23.40±3.65)ng/L,(1.33±0.32)×109/L and(12.58±2.13)mg/L](P＜0.05).⑤The total incidence rate of adverse reactions in experimental group(6.10％)was not statistically different from that in conventional group(5.26％)(P＞0.05).Conclusion For patients with COPD,compared with budesonide nasal spray+formoterol fumarate inhalation solution,triple compound inhalation aerosol can more effectively enhance pulmonary function,improve blood gas indicators,and reduce inflammatory response,with exact efficacy,high safety and promotion value.
Keywords：pulmonary diseasechronic obstructivedrug therapycombinationbudesonideformoterol fumaraterespiratory function testblood gas analysisinflammatory mediatorstreatment outcomes
Publication Date：2025-09-30
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：6( 1218-1223 )