Mechanism of tumorigenesis and cancer progression under the interaction of host genes and environmental exposure
CHEN Zhinan
BIAN Huijie
HUANG Wan
Abstract：As cancer research advances,its hallmark characteristics have been clearly defined.However,the molecular mechanisms underlying the systemic manifestations of tumors and their ultimate causes of mortality remain incompletely elucidated.The key to future research lies in revealing the interactions between tumors and distant organs,as well as how environmental factors and host physiology influence tumors and their hosts,which is critical for the prevention and treatment of cancer.This field of study centers on cancer as a systemic disease,covering aspects such as the driving forces of tumorigenesis and progression,the tumor microenvironment,the host's macro-immunological landscape,aging,metabolism and obesity,circadian rhythms,neuro-cancer interactions,and the host microbiome.In-depth investigation into the interaction between host genes and environmental factors will provide a theoretical foundation for cancer prevention,improvement of patients' quality of life,and enhancement of treatment efficacy.
Keywords：tumor microenvironmentcancer immunologycellular senescencecircadian rhythmmicrobiomecancer metabolism phenomenongene-environment interactioninterdisciplinary research
Publication Date：2025-07-31
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：8( 841-848 )