Research progress on the role of oxidative stress in lung injury induced by sulfur mustard
GUO Shujun
SHI Minjie
MA Yao
ZHAO Yushun
LIU Sijia
LIU Jiangzheng
KONG Deqin
Abstract：Sulfur mustard(SM)is a classic erosive chemical agent with real threat,which can penetrate the human body through multiple ways to cause poisoning.Lung is one of the main target organs of SM poisoning.Lung injury induced by SM includes pulmonary fibrosis,bronchitis,etc.,which is one of the main causes of death caused by SM.So far,the mechanism underlying SM poisoning is unclear,and there are no effective drugs for treatment.Oxidative stress plays a key role in SM-induced lung injury.This paper reviews the recent research progress on oxidative stress in lung injury caused by SM,and mainly introduces the role of oxidative stress in lung injury caused by SM from three aspects:inducing DNA damage,stimulating the synthesis of inflammatory factors and triggering cell apoptosis.The mechanism of SM-induced oxidative stress in lung is also discussed from the perspective of overproduction of reactive oxygen species/reactive nitrogen species and inhibition of antioxidant system leading to the imbalance of redox homeostasis,aiming at providing reference for the research and development of antioxidants.
Keywords：sulfur mustardoxidative stressreactive oxygen specieslung injuryantioxidant
Publication Date：2025-06-30
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：5( 818-822 )