Comparative study on blood lipid and liver function of officers and soldiers stationed at high altitude and plain

DONG Xiaotian; GAN Yu; GUAN Yufan; AN Jiaze

doi:10.13276/j.issn.2097-1656.2025.04.020

Abstract：Objective To investigate the relationship between high-altitude hypoxia environment and blood lipids and liver function.Methods A total of 5 034 officers and soldiers stationed in Golmud,Qinghai Province(at an altitude of 2 900 m)and Yantai,Shandong Province(at an altitude of 30 m)who underwent physical examination in a military hospital from June to July 2022 were selected and divided into plain group(n=1 795)and plateau group(n=3 239).The baseline data and the results of liver function and blood lipids were collected,and the correlation between them was analyzed by Spearman correlation analysis and multiple linear regression.Results There were statistical differences in total cholesterol(TC),aspartate aminotransferase/alanine aminotransferase(AST/ALT),high-density lipoprotein cholesterol(HDL-C),total protein,total bilirubin,direct bilirubin,indirect bilirubin,hemoglobin,red blood cell count,albumin/globulin ratio,and total bile acid between plain group and plateau group.The results of multiple linear regression showed that age,body mass index(BMI),living time at high altitude,sex,smoking and exercise could be used as influencing factors of triglyceride(TG),while the influencing factors of TC were age,BMI,living time at high altitude,smoking and exercise.At the same time,TC,TG and HDL-C were also influencing factors of AST/ALT in addition to age,BMI,living time at high altitude and sex.Conclusion Hypoxia at high altitude as an influencing factor can increase the blood lipid index of human body,and the changes of blood lipid can affect liver function together with age,BMI and other factors.