Mechanism of action of Yishen pill in treating chronic glomerulonephritis based on network pharmacology
XU Haonan
WANG Fang
LIU Shuting
HAN Li'na
ZHU Yingran
XU Lei
Abstract：Objective To explore the active ingredients and pharmacodynamic mechanism of Yishen pill in treating chronic glomerulonephritis(CGN).Methods The potential active ingredients and related targets of Yishen pill were searched through TCMSP.The targets of CGN were obtained from GeneCards.The common targets and potential active ingredients were imported into Cytoscape 3.7.2 software to construct the interaction network of herbs-ingredients-common targets-disease and obtain the core active ingredients.The protein-protein interaction network of common targets and core targets were obtained by STRING 11.0 database.GO functional enrichment and KEGG pathway enrichment analyses were performed using Metascape database.Core active ingredients and core targets were selected for molecular docking verification by AutoDock Vina software.Results A total of 115 potential active ingredients of Yishen pill and 2 765 targets of CGN were screened,including 135 common targets between potential active ingredients and disease.Core ingredients included quercetin,luteolin,etc.Core targets included TNF,IL6,AKT1,etc.KEGG enrichment analysis mainly involved pathways in cancer,etc.The results of molecular docking showed that the core ingredients had good binding activity with the core targets.Conclusion Yishen pill may act on TNF and other targets through quercetin and other core ingredients in the treatment of CGN,which lays a foundation for further elucidating the pharmacodynamic material basis and mechanism of Yishen pill.
Keywords：Yishen pillchronic glomerulonephritisnetwork pharmacologymolecular dockingmechanism of action
Publication Date：2025-04-30
Online Publishing Date：2026-08-26(First online date of this platform, not the publication date of the document)
Pages：8( 507-513,520 )